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J Pak Med Assoc. 2014 Jun;64(6):644-8. Effects and outcome of Tamsulosin more than just stone clearance after extracorporeal shock wave lithotripsy for renal calculi.      4/10/2016

Qadri SS, El Khalid S, Mahmud SM.
To determine the effect of Tamsulosin, as adjunctive medical therapy after Extracorporeal Shock Wave Lithotripsy for renal stones on rate of stone clearance, clearance time, pain intensity during stone clearance, steinstrasse formation and auxiliary surgical intervention required.
A prospective randomized controlled study was carried out in 120 patients who undeiwent ESWL for renal stones of 0.5-2.0 cm. They were randomized into study and control group in which Tamsulosin 0.4 mg/day was given in former as an adjunctive medical therapy. All patients underwent ESWL every 2 weeks until complete stone clearance for 8 weeks. The parameters assessed were stone clearance, clearance time, pain intensity and effect on steinstrasse.
Of the 120 patients 60 were in each group. The stone clearance rate was greater in study than in control group, 58 (96.7%) vs. 48 (80%) respectively, (p < 0.004). The mean stone clearance time was observed earlier in study group as compared to control group with significant statistical difference in stone size between 0.6-1.Scm.The mean intensity of pain patients experienced according to Visual analogue scale (VAS) was significantly less in study group (p < 0.002). The rate of steinstrasse formation was observed to be higher in control than in study group 15 (25%) vs 6 (10%) respectively (p < 0.003), while its spontaneous clearance was higher in study group than in control group 83.3% vs 33.3% (p < 0.03).
Tamsulosin significantly increases stone clearance after shock wave lithotripsy for renal stones. It also appeared to facilitate earlier stone clearance, reduces severity of pain, reduces the incidence of steinstrasse formation and tends to facilitate its spontaneous clearance.

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