Home           ::Data center           :: Weekly Schedule         :: Regulations           :: Gallery           ::Contact Us

:: Gallery   :: Tehran laparoscopy and endourology center office  

 What do you think about this site?

Educational centers, hospitals and research Sina

Combined Value of Validated Clinical and Genomic Risk Stratification Tools for Predicting Prostate Cancer Mortality in a High-risk Prostatectomy Cohort.      10/1/2017


Eur Urol. 2014 Jul 2. pii: S0302-2838(14)00521-1. doi: 10.1016/j.eururo.2014.05.039


We compared two previously validated post-RP classifiers-the Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) and the Decipher genomic classifier (GC)-to predict prostate cancer-specific mortality (CSM) in a contemporary cohort of RP patients.Both GC and CAPRA-S were significant independent predictors of CSM. GC was shown to reclassify many men stratified to high risk based on CAPRA-S 6 alone. Patients with both high GC and high CAPRA-S risk scores were at markedly elevated post-RP risk for lethal prostate cancer. If validated prospectively, these findings suggest that integration of a genomic-clinical classifier may enable better identification of those post-RP patients who should be considered for more aggressive secondary therapies and clinical trials.


Comments :
Comments via the form
name :
email :
WebPage :
Comments :
Tehran Laparoscopy and Endourology Office All rights reserved