Persian

 

                       Home           ::Data center           :: Weekly Schedule         :: Regulations           :: Gallery           ::Contact Us

:: Gallery   :: Tehran laparoscopy and endourology center office  
 



 What do you think about this site?
 






Educational centers, hospitals and research Sina

 
Uric Acid Levels Correlate with Baseline Renal Function and High Levels are a Potent Risk Factor for Postoperative Chronic Kidney Disease in Patients with Renal Cell Carcinoma      11/4/2014

 

 

 

The Journal of Urology
Volume 189, Issue 4 , Pages 1249-1254, April 2013
 
We investigated the relationship between preoperative uric acid and the glomerular filtration rate preoperatively and postoperatively in patients with renal cell carcinoma.

Materials and Methods

Included in study were 1,534 patients who underwent radical or partial nephrectomy for renal cell carcinoma between 1994 and 2008. Uric acid was measured preoperatively. The estimated glomerular filtration rate was calculated using the MDRD (Modification of Diet in Renal Disease) equation preoperatively and postoperatively within 7 days, and at 3 months, and 1 and 3 years. We looked for correlations of uric acid with the glomerular filtration rate, patient demographics and comorbidities. We also evaluated the predictive value of uric acid for the preoperative glomerular filtration rate and new onset chronic kidney disease, defined as a glomerular filtration rate of less than 60 ml/minute/1.73 m2, after nephrectomy using multivariate regression analysis.

Results

Mean ± SD uric acid was 5.2 ± 1.5 mg/dl (range 1.3 to 11.3). Mean preoperative uric acid correlated with the preoperative glomerular filtration rate (r = –0.313, p <0.001) and was associated with prevalent chronic kidney disease. On multivariate regression analysis a decreased preoperative glomerular filtration rate correlated significantly with earlier year of surgery, older age, male gender, hypertension, high uric acid and larger tumors (each p <0.001). Hypertension, male gender and high body mass index correlated with high uric acid (each p <0.001). Older age (p <0.001), diabetes mellitus (p = 0.002), low preoperative glomerular filtration rate (p <0.001) and high preoperative uric acid (p = 0.002) were significant predictors of new onset chronic kidney disease 3 years after nephrectomy.

Conclusions

Increased preoperative uric acid was an independent predictor of a low preoperative glomerular filtration rate and new onset chronic kidney disease in patients with renal cell carcinoma who

 

 

 

 

Comments :
Comments via the form
name :
email :
WebPage :
Comments :
 
Tehran Laparoscopy and Endourology Office All rights reserved